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The rationale above is mechanism-based community reasoning, not direct combination evidence

In order to improve outcomes, biphasic scaffolds can be created with a softer upper layer containing chondrogenic factors (e.g., TGF-, chondroitin sulfate) and a stiffer lower layer, often loaded with calcium phosphate, hydroxyapatite, or bone morphogenetic protein (BMP), to provide structural support of the above cartilage layer and to promote osteogenic tissue formation and boney integration

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Engage formulation scientists early in the evaluation process, not after the commercial and IP analysis is complete

Injections can also cause firmness under the skin due to lipohypertrophy, allergic reactions, and infections