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Cell death induced by combined deprivation of amino acids and serum was typical apoptosis, associated with caspase activation (Figure 1D) and characteristic morphological changes, such as chromosomal condensation, membrane blebbing, and formation of apoptotic bodies (Movie S1)

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Here are some key concerns: Increased Oxidative Stress : A decrease in glutathione levels can lead to increased oxidative stress, which is associated with various chronic diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders

Metals stored in tissues release gradually, requiring consistent glutathione support

10.1182/blood.V86.4.1564.bloodjournal8641564 149