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These results established the 2.4mg dose as the primary research target

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Under pathological conditions, disruption of TFAM can lead to mtDNA mispackaging, a massive release of damaged mtDNA, and down-regulation of TFAM also reduces the stability of the mtDNA mimetic nuclear structure (West et al., 2015)

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(GLP-1s are FDA-approved for managing type 2 diabetes and for weight loss)
