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inactive mutant forms of CDO (e.g., His86Ala, leading to loss of the His that serves as a metal ligand in the active site) did not form any cross-link, and mutant forms of CDO with low activity (e.g., Arg60Ala, which has a markedly decreased affinity for Cys, probably due to the loss of the hydrogen bonding partner for the carboxylate of the substrate) formed the cross-link more slowly

How Is Meralgia Paresthetica Treated

Note: Percentages may not add to 100 due to rounding

Allergic reactions Allergy to vitamin B12 is quite uncommon, but some people might experience allergic symptoms, especially when they first start supplementing

The tolerability gap may be less significant in practice than the raw nausea percentages suggest