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Hence, DILI not only cause patient hospitalization and sometimes need for liver transplantation and even death, but also involve the loss of potentially useful drugs

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Values were normalised and reported as M of reduced glutathione per mg of protein ( 2.12 Measurement of myeloperoxidase activity Neutrophils are primary responders to inflammation, which can be studied by quantifying the activity of myeloperoxidase, an enzyme abundantly present in their granules ( 2.13 Histopathological examination Liver and pancreatic tissues were duly fixed in formalin (10%) solution to preserve structural integrity and prevent decomposition

6) LPS-induced group pre-treated with indomethacin received tween 20 (1 mL/kg/day) for 11 d followed by indomethacin (5 mg/kg) for 3 d followed by LPS (2 mg/kg for 6 h) and 7) LPS-induced group pre-treated with BCSO (0.2 mL/kg/day) dissolved in tween 20 for 11 d followed by reduced dose of indomethacin (2.5 mg/kg) for 3 d followed by LPS (2 mg/kg for 6 h)

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