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Subsequent studies revealed that IGF-1 alleviates a number of autoimmune conditions, including autoimmune diabetes and contact dermatitis, and that its protective effect appears to be correlated with increased infiltration by regulatory T cells in affected tissues [214216]

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doi:10.1093/carcin/bgs006, PMID: 22235026 Wachsman JT (1997) DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis
Metal-polyphenol self-assembled nanodots for NIR-II fluorescence imaging-guided chemodynamic/photodynamic therapy-amplified ferroptosis

When Phase 2 pathways are adequately supported, activated metabolites from Phase 1 are safely neutralized and prepared for elimination through bile and urine
