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This population is phenotypically heterogeneous, likely accounting for the clinical frustrations of patients and practitioners and the failures of numerous therapeutic trials

Instead, PLLA particles elicit a controlled fibroblastic responses that eventuates in new collagen formation

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Bregman provides thorough clinical and electrodiagnostic evaluation, conservative and regenerative options, and surgical decompression of the posterior tibial nerve when indicated

In PD, collagen-dense plaques with diffusion-limited architecture restrict uniform penetration and retention of biologic agents