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Alcohol has a very similar mechanism of tolerance and withdrawal to benzodiazepines, involving the GABAA, NMDA, and AMPA receptors [237], and thereby, the extent of this counteraction should be indicative of the observed effects [63,64]

150,151 The generation of reactive oxygen species is further augmented by decreased expression of the anti-oxidant enzymes superoxide dismutase 1 and 3 and isoforms of nitric oxide synthase

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