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PDK1 knockout reduced the phosphorylation level of PDHE1 and upregulated the activity of PDHC, thus inhibiting LPS-induced anaerobic glycolysis and the polarization of macrophages from an M2 to an M1 phenotype and, consequently, reducing the levels of the inflammatory mediators interleukin (IL)-6, IL-12, and IL-1

Braz J Biol 84:e285332
More specifically, a ferroptosis inhibitor and vitamin E diet ameliorate hippocampal neurodegeneration in forebrain neurons in mice that have undergone a conditional knockout of Gpx4 [32]

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Probiotics and the gut immune system: indirect regulation