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It is possible that dysregulated glutathione metabolism in mitochondria may promote necroptosis by altering the function of PGAM5 (phosphoglycerate mutase family member 5) and DRP1 (dynamin-related protein 1), mitochondrial proteins that are known to be associated with the necrosome (21, 22)

Ma X, Zhang B, Miao R, Deng X, Duan Y, Cheng Y, Zhang W, Shi M, Huang K, Xia XQ (2020) Transcriptomic and physiological responses to oxidative stress in a Chlamydomonas reinhardtii glutathione peroxidase mutant

J Cell Mol Med 25:20402051

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

110 In individuals with progressive myoclonus epilepsy, the presence of a GSTT1-null genotype has been linked to a heightened risk of developing the condition, potentially amplifying susceptibility to oxidative stress
