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We demonstrated that the accumulated fumarate leads to oxidative stress by covalently binding to reduced GSH in a non-enzymatic reaction that forms succinicGSH
The levels of GSH and MDA were estimated by the methods which were described by Beutler et al., [11] and Buege et al., respectively [12]

J.LevineJ

Your liver produces it naturally, and nearly every cell in your body depends on it
Immunol., 192 , 41344144
