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ROS are highly reactive molecules mainly involved in various redox reactions in the body and serve important defensive functions

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

doi: 10.1002/ijgo.70538

Chronic ethanol feeding Male mice (1012 wk old) were fed a modified Lieber-DeCarli (LD) diet (F4473SP and F4474SP

Demiryilmaz I, Uzkeser H, Cetin N, Hacimftolu A, Bakan E, Altuner D