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In addition, IFNG stimulates ACSL4 expression through an IRF1 (interferon regulatory factor 1)-dependent mechanism, thereby augmenting arachidonic acid-related ferroptosis in animal models and impeding tumor growth [187] (Fig

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Both NO and CO activate soluble-guanilyl cyclase (sGC), thus inducing and increase in intracellular cyclic-guanilyl monophosphate (cGMP) as second messenger [8, 9]

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