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[DOI] [PubMed] [Google Scholar] 106.Della Bella C., Soluri M.F., Puccio S., Benagiano M., Grassi A., Bitetti J., Cianchi J., Sblattero D., Peano C., DElios M.M

it enables cells to cope with various forms of stress (e.g., nutrient deprivation, endoplasmic reticulum (ER) stress, pathogen infection, and hypoxia) and is considered a survival mechanism 5

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The extrinsic pathway is activated upon the binding of cellular death ligands, including FasL and TNF-, to their specific cell-surface receptors, resulting in the recruitment of adaptor proteins and activation of initiator caspases, in particular caspase-8 [73]