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doi: 10.3389/fphar.2026.1783888 Received 08 January 2026 Revised 23 February 2026 Accepted 23 March 2026 Published 15 April 2026 Volume 17 - 2026 Edited by Jos Roberto de Oliveira Ferreira, Universidade Estadual de Cincias da Sade de Alagoas, Brazil Reviewed by Ruolan Li, University of Electronic Science and Technology of China, China Ramoji Kosuru, Versiti Blood Research Institute, United States Updates Copyright 2026 Scenna, Bej, Cesare, Persichitti, Cimini, DAngelo and Castelli

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Nascas animal studies suggest that acetyl-L-carnitine, a crucial mediator of fat metabolism and energy production throughout the body, plays a special role in the brain, where it works at least in part by preventing the excessive firing of excitatory nerve cells in brain regions called the hippocampus and frontal cortex

The compounds have defined saturation points in hepatic tissue, and exceeding them provides no additional benefit while increasing the risk of gastrointestinal distress or methionine toxicity