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Konzo is characterized by a sudden onset of a non-progressive spastic paraparesis of varying severity, evolving as a mild (stage 1), moderate (stage 2), or severe (stage 3) form of neurodisability 1

Once acetaldehyde is obtained from ethanol metabolism, aldehyde dehydrogenase (ALDH) converts it into acetate, but if the system is overloaded, the excess of acetaldehyde reacts with mitochondrial GSH (mGSH), depleting the mitochondrial pool [143]

200 years of pain therapy with opioids)

Advances and challenges of liposome assisted drug delivery

The MCK mouse heart model of Friedreichs ataxia: alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation