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444 Incorporating O 2 -dependent myoglobin (Mb) into Gd-NTs (MbO@Gd-NTs) alleviates tumor hypoxia, amplifies Gd-Tex-induced ROS production, enhances radiosensitization, and induces long-term antitumor immune memory

Collectively, these observations highlight myelin degeneration as an early event and significant pathological feature in AD progression, which may contribute to disease-related cognitive decline

This leads to production of pro-fibrotic proteins (e.g., ZO-1, MUC2) and fibroblast markers (e.g., FGF-1, SMA) in epithelial cell, resulting in mesenchymal transformation and extracellular matrix collagen accumulation (Wang K

The supplementation was safe and well-tolerated over 12 months, with no adverse effects, hypoglycemia, or significant changes in liver or kidney function

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