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most cases appear to be sporadic, in which both genetic and environmental risk factors play a role 7 , while a small proportion arise from monogenic mutations

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3.4 Profiling the exo- and endo-metabolome In some situations, analyzing the exometabolome (i.e., the metabolites released by released cells), can be advantageous because it allows direct assessment of the metabolome changes in the culture media without disrupting the cell culture or extracting the metabolites from the cellular matrix, simplifying the monitoring of time-course events

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L.FujiokaH.LiangJ.et al