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AOD-9604 targets fat cells primarily through beta-3 adrenergic receptors, which are G-protein coupled receptors predominantly expressed in adipose tissue
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3.1.4 TGF- family signaling in breast cancer progression TGF- exhibits a paradoxical role in breast cancer pathogenesis: During early tumorigenesis, it exerts growth-suppressive effects on normal and premalignant mammary epithelium, whereas advanced malignancies develop resistance to these tumor-suppressive signals, enabling TGF- to drive oncogenic progression (74)
[DOI] [PubMed] [Google Scholar] 94.Ferraroni M., La Vecchia C., DAvanzo B., Negri E., Franceschi S., Decarli A
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