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However, intrinsic or acquired resistance to CDK4/6 inhibitors is a frequent event, limiting the success of these treatments 4,5

These include the presence of antioxidants that already exist in the body, making the benefits of administered antioxidants difficult to verify

However, more importantly, it also meets the societal demands to reduce the number of animals in drug development

Consequently, exercise-induced mitobiogenesis in skeletal muscle was shown to be mediated through the calcium/CAMK/p38 MAPK/PGC-1 pathway, which is crucial for skeletal muscle adaptation to exercise training

doi: 10.1038/nature09614 22 GabbayKHMerolaLOFieldRA
