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This would seem to be a potentially fruitful area for further research since the major environmental risk factors for PDexposure to pesticides, trichloroethylene, and air pollutionare likely to have their effects on dopaminergic neurodegeneration via toxic effects of oxidative stress and inflammation 61

Wick, A

L-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs
Ridley et al., 1991

This makes life much harder for those with the gene defect increasing the deficiency of the already reduced ability to absorb and use folate
