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It is a lipid-soluble drug that binds steroid alcohols (ergosterol) in the fungal cell membrane, causing leakage of cellular content and death

Weight loss induced by lifestyle interventions or GLP-1RAs reduces circulating leptin and increases adiponectin, shifting the immune balance toward greater Treg activity and reduced Th1/Th17 responses [36,37]

Refer to the purging guide to distinguish between normal adjustment and genuine problems

Filling Real-World Data Gaps We need to fill in data gaps for historically underrepresented populations by applying real-world data (RWD) from genomics and real-world evidence (RWE) from publicly available epidemiology and socioeconomic sources