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For instance, activating AMPK/SIRT1 pathways to enhance neuronal GSH precursor supply or targeting Nrf2-dependent antioxidant gene expression, particularly addressing SIRT1 hypofunction in Alzheimers disease, may optimize neuroprotective outcomes by addressing patient-specific metabolic vulnerabilities (Simon et al., 2020)

Womens Health Study (WHS) is another comprehensive study in the United States involving nearly 40,000 healthy women, with a minimum of 45 years of age who received 600 IU of vitamin E administered on alternate days, and who were followed for a period of 10 years (Lee et al., 2005)

(3) while nasal bioavailability for smaller drug molecules is advantageous

NIR responsive composite nanomaterials with in-situ deposition of cascaded nanozymes for multiple synergistic therapy of bacterial infection in diabetic mice