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18, 2737.10.1016/j.tem.2006.11.006 66 McCormickM.ChenK.RamaswamyP.KenyonC

Within dopaminergic terminals and in synaptic clefts, excess DA is autoxidized to quinone or semi-quinone (LaVoie and Hastings, 1999) to generate large amounts of H 2 O 2 , OH - , and O 2 - (Baumann et al., 2002)

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Further exploration in these areas will be essential for clarifying the pathophysiological contributions and achieving a more comprehensive understanding of diseases, thereby aiding the development of more effective prevention strategies