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Neuroinflammation plays a key role in the progression of PD

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This conclusion is supported by multiple lines of evidence: in wild-type cells, (1) histone K la can be labeled and induced by isotopic l-lactate as we previously reported 11

Whereas levothyroxine (T4) predominates in thyroidal secretion, peripheral de-iodination rapidly converts only a fraction of circulating T4 into T3

Additionally, SF administered at 28.2 mol/kg/day for 4 months (62), 141 mol/kg/day for 80 days (63), or 141 mol/kg/day for 5 months (64) ameliorated spatial cognitive impairment, reduced A plaques, and regulated specific HDACs, resulting in diminished plaque burden in other AD mouse models (6264)