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Science 291 , 19871991 (2001)
The Bottom Line While exposure to heavy metals is a reality of modern life, toxicity doesnt have to be
M.EdwardsW.RagusaJ
References Noctor, G., Cohen, M., Trmulot, L., et al
Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]
