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DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine)

Metformin is known to impact cellular levels of NAD + , ATP, and tricarboxylic acid intermediates, as well as AMPK, which affect epigenome modification enzyme activity [166]

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