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These different results could be accounted for by both the expression of NADPH oxidase induced by KRAS G12D overexpression, which leads to ROS generation, and an increase in NRF2-dependent ROS scavenging in cells expressing physiological levels of KRAS G12D
The participants compliance regarding capsule consumption was calculated as percentages of the number of duly taken capsules (as noted by participants) compared to the number of capsules provided in the protocol
