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Reconstituted peptides are thermally unstable and begin degrading within hours at room temperature

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In certain embodiments, the preservative employed in any auris-compatible formulation described herein is an antioxidant (e.g., butyl hydroxytoluene (BHT) or the like, as described herein)

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Disruption of estrogen signaling in zebrafish retina using known estrogen receptor modulators such as tamoxifen and 4-OH-A (formestane) alter eye development and retinal thickness 94 , suggesting proper estrogenic signaling is important for normal eye development

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