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Studies suggest that the average patient will not get any clinical benefit from T4 therapy until TSH rises above approximately 10 mU/L

Whats missing is strong, long-term evidence that long-term microdosing produces comparable outcomes in weight, blood glucose control, and reduction of cardiovascular risk

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A 50mg vial with 5mL yields 10mg/mL a 5mg dose requires 0.5mL (50 units), easier to measure accurately than 0.2mL at 25mg/mL concentration