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Sonoshita, M
The JM domain is a crucial region of c-MET, responsible for the negative regulation of the receptor and downstream signaling pathways
In many systems, the affinity ligand is directly attached to the bead
Escitalopram is first metabolized via N-desmethylation to S-desmethylcitalopram by CYP3A4 and CYP2C19 (Kobayashi et al., 1997), and this metabolite is subsequently demethylated mainly by CYP2D6 to form S-didesmethylcitalopram (von Moltke et al., 2001)
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