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Stephen Matta DO MBA CAQSM Dr

In this Review, we focus on advances in our understanding of inhibition of the HGF/c-MET pathway in patients with gastro-intestinal cancers, the prominent challenges facing the clinical translation and implementation of agents targeting HGF/c-MET, and discuss the various efforts, and associated obstacles to the discovery and validation of biomarkers that will enable patient stratification in this context

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Several types of ion channels in the ECs have been described including K + channels, Ca 2+ -activated K + channels, Cl channels, Ca 2+ channels, and Na + channels [24, 25, 51]