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It is not intended for human consumption, veterinary use, diagnostic purposes, or therapeutic applications

The rate was highest in the first month of treatment

The preclinical research suggests the receptor upregulation is time-dependent, so this is a real question

The key effects are well-established: accelerated cell turnover (the outer layers of the stratum corneum, the skin's surface barrier, shed more quickly), direct stimulation of procollagen genes, and suppression of matrix metalloproteinases - the enzymes responsible for breaking down existing collagen

While they are safe for many people, its important to consult with a healthcare provider to determine if they are appropriate for you, especially if you have any underlying health conditions or are on certain medications.