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Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

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The wet weight of each sample was immediately measured by an electronic balance, following which the brains were dried at 100C for 24 h to obtain the dry weight

In addition to new and more efficacious mitochondrial ROS scavenging compounds, given that ROS can play a role in both physiological and pathological signaling, understanding the differences between these two modes and developing strategies to mitigate pathological ROS damage while preserving physiological ROS signaling will be an important next challenge