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7 Conclusion In summary, this paper offers a detailed review of various mechanisms by which natural products treat EMs by targeting various forms of PCD and its key signaling pathways

Maternal betaine intake (rats and pigs) can programmatically alter liver metabolism, cell proliferation, and the developmental trajectory of offspringand even the F2 generationby affecting the DNA methylation pattern of the insulin-like growth factor (IGF) gene family (IGF-1/2) in the liver of the offspring and regulating the expression of glucocorticoid receptor signaling and lipolysis genes (adipose triglyceride lipase and hormone-sensitive lipase) (25, 140145)