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When stimulated by external pathological factors, IB kinase is activated, dissociating the trimeric complex and thus activating NF-B p65, which enhances bone resorption by up-regulating NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammatory vesicle responses [116]

Targeting Inflammation and Oxidative Stress Inflammation is one of the primary determinants of cancer, and inflammatory responses are also key characteristics of cancer

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