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Here, we report our discovery that masked nitrile-oxide electrophiles, which have not been explored previously as covalent cellular probes, undergo remarkable chemical transformations in cells and provide an effective strategy for selective targeting of GPX4

YokoyamaONishizawaOHommaYTakedaMGotohMKakizakiHet alNocturnal polyuria and hypertension in patients with lifestyle related diseases and overactive bladder

The Seidel test detects aqueous humor leakage and corneal perforations or a significant injury and assesses the integrity of the eyes anterior segment

However, prolonged exposure of neurons to glutamate leads to cell death by elevating the intracellular Ca 2+ that subsequently generates free radicals and induces apoptosis in the neuronal cells (Ola et al., 2013)

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4- fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2- azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist