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In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]

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Following PRACs safety review, the EMA further identified affected areas including the musculoskeletal system, nervous system, psychiatric health, and the senses, with examples such as tendonitis, tendon rupture, joint or limb pain, gait disturbance, neuropathies associated with paraesthesia, depression, fatigue, memory impairment, sleep disorders, and impaired hearing, vision, taste, or smell

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