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doi: 10.3389/fphar.2025.1516601 Received 24 October 2024 Accepted 04 February 2025 Published 24 February 2025 Volume 16 - 2025 Edited by Ewa Litwa, Polish Academy of Sciences, Poland Reviewed by Stefano Comai, University of Padua, Italy Archita Venugopal Menon, Beam Therapeutics, United States Updates Copyright 2025 Zhao, Ren, Luo, Li, Cheng, Wen, Wu and Zhou

Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction

GCLM: Glutamate-cysteine ligase modifying subunit

Many transcription factors and signaling molecules have critical cysteine residues that can be oxidized and this is an important mechanism whereby reactive oxygen and nitrogen species (ROS and RNS) regulate protein function and cell signaling that can be modulated by GSH [13,15]