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Strikingly, increasing cellular L2HG levels by knockdown of L2HG dehydrogenase (the only known enzyme that oxidizes L2HG back to -KG) decreased mitochondrial oxygen consumption and lactate production, which indicates that L2HG could inhibit both mitochondrial respiration and glycolysis to blunt their production of NADH and to mitigate attendant reductive stress (72)

The transplanted cells could result in tumors or have other unfavorable outcomes

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Using it in humans, marketing it for human use, or implying therapeutic benefits in promotional material triggers FDA enforcement authority