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In addition, cardiolipin is also known to induce NLRP3 inflammasome activation upon the presence of PAMPs or antibiotics [20, 21]

Clinical box Pyruvate kinase deficiency A child presented with jaundice and abdominal tenderness, which developed following a severe cold

This has been hypothesized to result from aspirin-induced inhibition of urate reabsorption (aspirin inhibiting a different urate transporter involved in reabsorption) in the proximal tubule (Figure 2)