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Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles

In one controlled trial, supplementation with 500 mg per day of vitamin C lowered oxLDL from 87 U/L to 71 U/L, representing an 18% reduction, with no significant change in overall LDL cholesterol levels

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The broad substrate scope of NPC2 could explain the more pronounced phenotypes in yeast when NPC2 is deleted, such as sterol accumulation, reduced vacuolar fusion, loss of raft-like domains in the limiting membrane, and, ultimately, vacuolar fragmentation (27, 57, 58)

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