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Combined Application Rationale The theoretical basis for combination use rests on the complementary mechanisms: BPC-157's strength in promoting vascularization and anti-inflammatory effects combines with TB-500's cellular migration and tissue remodeling capabilities

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Three key epithelial-derived alarmins TSLP, IL-25 and IL-33 act primarily through innate lymphoid cells type 2 (ILC2s) and dendritic cells to orchestrate type 2 immune responses and contribute to the pathobiology and pathophysiology of allergic responses

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Secondly, validation of the FDX1 gene knockout remains insufficient and further genetic manipulation is required to confirm causality
