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Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

On the other hand, in some diseases, it has been identified that some Th1-type cells produce INF-y and are capable of producing IL-10 [37], the expression of these cytokines could have a cooperative effect in reducing the expression levels of TNF- [38]

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Acknowledgements We wish to thank the study participants from Complete Fertility, Southampton for making this project possible as well as the staff at the institutions for assistance in project management

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