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Patients with inflammation of the joint are often excluded from cartilage repair attempts given that catabolic cytokines and proteinases (MMPs) present in the synovial fluid degrade the native ECM, and would similarly degrade any implanted tissue, predisposing treatment failure

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Haber S.N

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

Furthermore, astrocytes regulate synaptic function by modulating synaptic transmission and plasticity, buffering extracellular K + , taking up neurotransmitters, and releasing gliotransmitters