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Niacin also contributes to the synthesis of neurotransmitters, such as serotonin, a derivative of tryptophan, which is pivotal for mood regulation and various neurological functions, such as sleep and appetite, besides impacting cognitive and executive functions (, )

45 In hereditary elliptocytosis, the membrane fails to rebound from deformation, and RBCs progressively elongate to form visible elliptocytes, which causes a mild to severe hemolytic anemia

Cell 108, 271282

4.1 Release and recognition of mtDNA The release of mtDNA has been implicated as a potent DAMP that leads to inflammatory responses

Nature 524, 309314