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did note interactions between this system and antidepressant use
10.3390/gels10080531 14 Al-MuthefferE

Liu Y, Yang J, Hilliard TS, Wang Z, Johnson J, Wang W, Harper EI, Ott C, OBrien C, Campbell L, Crowley B, Grisoli S, Stavrou NM, Juncker-Jensen A, Stack MS (2023) Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy

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a "co-stimulatory signal, as used herein, refers to a signal, that in combination with a primary signal, such as TCR/CD3 ligation, leads to T cell proliferation and/or upregulation or downregulation of key molecules
