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NADPH oxidase in the macrophage plasma membrane is activated to produce , which is then converted to H 2 O 2 by superoxide dismutase

It challenges the current diagnosis procedure which are based on observable characteristics [19] (generic symptoms and subjective questionnaires) and rely on continuously evolving case definitions (Fukuda 1994 [20], Canadian Consensus Criteria 2003 [21], International Consensus Criteria 2011 [2], National Academy of Medicine 2015 [22], UK National Institute for Health and Care Excellence 2021 [23])

This is a pegylated prodrug conjugated with the aptamer of the anti-vascular endothelial growth factor (VEGF) used in the treatment of age-related macular degeneration (AMD) [17], a common