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10.3389/fgene.2020.565854 Front
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The serum level of intact IGFBP3 is normal in CKD, while the fragmented fraction (29 kDa) is increased but has a reduced affinity for peptides [24]

3.4.1 Inflammatory Markers IF has been linked to reducing systemic inflammation, as indicated by lowered circulating levels of significant inflammatory markers, including C-reactive protein (CRP) and interleukin-6 (IL-6) [63, 64]