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In 2021, Sun and colleagues reported a pioneering library of cereblon-based PROTACs targeting the degradation of glycogen synthase kinase 3 (GSK-3), a protein kinase considered a therapeutic target in neurodegenerative diseases

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In the transcriptomic landscape, DTC can be classified according to its gene expression profile, and each subtype has a distinct mutational profile, intracellular signaling output, and clinicopathological characteristics

Methods Enzymol 300:21926 Orlowski M, Karkowsky A (1976) Glutathione metabolism and some possible functions of glutathione in the nervous system

Efficient production of glutathione with multi-pathway engineering in Corynebacterium glutamicum
